Update on Electrophysiology in Schizophrenia

Authors

Robert W. McCarley, Harvard Medical School
Brian F. O'Donnell, Harvard Medical School
Margaret A. Niznikiewicz, The Massachusetts Mental Health Center
Geoffrey Potts, Harvard Medical SchoolFollow
Yoshio Hirayasu, Harvard Medical School
Paul G. Nestor, University of Massachusetts
Martha E. Shenton, Harvard Medical School

Document Type

Article

Publication Date

1997

Digital Object Identifier (DOI)

https://doi.org/10.1080/09540269775240

Abstract

Event-related potentials (ERPs) provide a non-invasive, functional method to evaluate neural activation and cognitive processes in schizophrenia, with a temporal resolution in the millisecond range, literally at the speed of thought. Auditory ERP components tested in schizophrenia, in order of latency of occurrence, include the P50 sensory gating response, the mismatch negativity, P300, and the N400 component. Abnormalities in these components demonstrate pervasive disruption of auditory processing as early as 50 milliseconds after stimulus onset. All of these abnormalities appear to tasks which require sensory memory or working memory operations. The anatomic substrates for these ERP components probably include the posterior superior temporal gyrus and medial temporal lobe structures. P300 topographic asymmetries have been associated with left posterior superior temporal gyrus abnormalities. Future work will focus on relating ERP abnormalities to specific neural circuit disturbances in this disorder.

Was this content written or created while at USF?

No

Citation / Publisher Attribution

International Review of Psychiatry, v. 9, issue 4, p. 373-386

Scholar Commons Citation

McCarley, Robert W.; O'Donnell, Brian F.; Niznikiewicz, Margaret A.; Potts, Geoffrey; Hirayasu, Yoshio; Nestor, Paul G.; and Shenton, Martha E., "Update on Electrophysiology in Schizophrenia" (1997). Psychology Faculty Publications. 1747.
https://digitalcommons.usf.edu/psy_facpub/1747