The stressed hippocampus, synaptic plasticity and lost memories
Document Type
Article
Publication Date
2002
Digital Object Identifier (DOI)
https://doi.org/10.1038/nrn849
Abstract
Stress is a biologically significant factor that, by altering brain cell properties, can disturb cognitive processes such as learning and memory, and consequently limit the quality of human life. Extensive rodent and human research has shown that the hippocampus is not only crucially involved in memory formation, but is also highly sensitive to stress. So, the study of stress-induced cognitive and neurobiological sequelae in animal models might provide valuable insight into the mnemonic mechanisms that are vulnerable to stress. Here, we provide an overview of the neurobiology of stress–memory interactions, and present a neural–endocrine model to explain how stress modifies hippocampal functioning.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Nature Reviews - Neuroscience, v. 3, p. 453-462
Scholar Commons Citation
Kim, Jeansok J. and Diamond, David M., "The stressed hippocampus, synaptic plasticity and lost memories" (2002). Psychology Faculty Publications. 1325.
https://digitalcommons.usf.edu/psy_facpub/1325
