Differential Sensitivity of Hippocampal Primed Burst Potentiation to Anesthetics
Document Type
Article
Publication Date
1990
Keywords
CA1, Long-term potentiation, Hippocampus, Urethane, Barbiturate, Corticosterone
Digital Object Identifier (DOI)
https://doi.org/10.1016/0006-8993(90)91536-P
Abstract
This study demonstrates that the anesthetics urethane and pentobarbital differentially affect a low threshold form of long-lasting synaptic plasticity, termed primed burst (PB) potentiation, in the CA1 area of rat hippocampus. PB potentiation was generated by the delivery of a 5-pulse patterned stimulus train, consisting of one priming pulse followed 170 ms later by a burst of 4 pulses at 200 Hz. PB potentiation could not be reliably generated in urethane-anesthetized rats unless stimulus currents were raised to 150% of baseline levels during the stimulus train. In pentobarbital-anesthetized rats, PB potentiation could always be evoked at baseline stimulus intensities. Differences between the anesthetics which could contribute to their varying effects upon PB potentiation are discussed.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Brain Research, v. 521, issue 1-2, p. 148-152
Scholar Commons Citation
Engstrom, David A.; Bennett, Catherine M.; Stevens, Karen E.; Wilson, Rebecca L.; Diamond, David M.; Fleshner, Monika; and Rose, Greg M., "Differential Sensitivity of Hippocampal Primed Burst Potentiation to Anesthetics" (1990). Psychology Faculty Publications. 1294.
https://digitalcommons.usf.edu/psy_facpub/1294
