The Influence of Depression on the Progression of HIV: Direct and Indirect Effects
Document Type
Article
Publication Date
3-2012
Keywords
disease progression, HIV, mental health
Digital Object Identifier (DOI)
https://doi.org/10.1177/0145445511425231
Abstract
The authors suggest a theoretical model of pathways of HIV progression, with a focus on the contributions of depression-as well as secondary, behavioral and emotional variables. Literature was reviewed regarding (a) comorbid depression and the direct physiological effects on HIV progression and (b) intermediary factors between HIV and disease progression. Intermediary factors included (a) substance use, (b) social support, (c) hopelessness, (d) medication nonadherence, and (e) risky sexual behavior and the contraction of secondary infections. The authors suggest direct physiological pathways from depression to HIV progression and indirect pathways (e.g., behavioral, social, and psychological). In addition to depression, substance use, poor social support, hopelessness, medication nonadherence, and risky sexual behavior seem to be integral in HIV progression. Based on the individual relationships of these variables to depression and HIV progression, a comprehensive multipath model, incorporating all factors, serves to explain how severe emotional distress may lead to accelerated progression to AIDS.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Behavior Modification, v. 36, issue 2, p. 123-145
Scholar Commons Citation
Schuster, Randi; Bornovalova, Marina; and Hunt, Elizabeth, "The Influence of Depression on the Progression of HIV: Direct and Indirect Effects" (2012). Psychology Faculty Publications. 112.
https://digitalcommons.usf.edu/psy_facpub/112
