Hyaluronidase-Facilitated High-Dose Subcutaneous IgG Effectively Controls Parvovirus B19 Infection in a Pediatric Cardiac Transplant Patient With Severe T-Cell Lymphopenia

Authors

Rachel J. Cruz, University of South Florida
Joseph F. Dasso, University of South FloridaFollow
Carla Duff, University of South FloridaFollow
Diane Krasnopero, Johns Hopkins All Children’s Hospital
Zsofia Long, Johns Hopkins All Children’s Hospital
Maryssa Ellison, University of South Florida
Daime Nieves, University of South FloridaFollow
Panida Sriaroon, University of South FloridaFollow
Alfred Asante-Korang, Johns Hopkins All Children’s Hospital
Jolan Walter, University of South FloridaFollow

Document Type

Article

Publication Date

2020

Keywords

parvovirus B19, heart transplant, pediatric, immunodeficiency, subcutaneous immunoglobulin

Digital Object Identifier (DOI)

https://doi.org/10.1093/ofid/ofaa076

Abstract

We treated three pediatric cardiac transplant patients with chronic parvovirus viremia with high-dose intravenous immunoglobulin (HD-IVIG). One patient with severe T-cell lymphopenia suffered recurrent viremia and aseptic meningitis, which resolved remarkably when he was switched to high-dose hyaluronidase-facilitated subcutaneous immunoglobulin (HD-SCIG-Hy). We discuss the advantages of HD-SCIG-Hy vs HD-IVIG treatment for similar cases.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Open Forum Infectious Diseases, v. 7, issue 5, art. ofaa076

Scholar Commons Citation

Cruz, Rachel J.; Dasso, Joseph F.; Duff, Carla; Krasnopero, Diane; Long, Zsofia; Ellison, Maryssa; Nieves, Daime; Sriaroon, Panida; Asante-Korang, Alfred; and Walter, Jolan, "Hyaluronidase-Facilitated High-Dose Subcutaneous IgG Effectively Controls Parvovirus B19 Infection in a Pediatric Cardiac Transplant Patient With Severe T-Cell Lymphopenia" (2020). Pediatrics Faculty Publications. 1.
https://digitalcommons.usf.edu/ped_facpub/1