Survival Outcome of Women with Stage IV Uterine Carcinosarcoma Who Received Neoadjuvant Chemotherapy Followed by Surgery
Document Type
Article
Publication Date
2018
Keywords
carboplatin, neoadjuvant chemotherapy, paclitaxel, stage IV, survival outcome, uterine carcinosarcoma
Digital Object Identifier (DOI)
https://doi.org/10.1002/jso.24861
Abstract
Background and Objectives: To examine survival of women with stage IV uterine carcinosarcoma (UCS) who received neoadjuvant chemotherapy followed by hysterectomy.
Methods: This is a nested case-control study within a retrospective cohort of 1192 UCS cases. Women who received neoadjuvant chemotherapy followed by hysterectomy based-surgery for stage IV UCS (n = 26) were compared to those who had primary hysterectomy-based surgery without neoadjuvant chemotherapy for stage IV UCS (n = 120). Progression-free survival (PFS) and cause-specific survival (CSS) were examined.
Results: The most common regimen for neoadjuvant chemotherapy was carboplatin/paclitaxel (53.8%). Median number of neoadjuvant chemotherapy cycles was 4. PFS was similar between the neoadjuvant chemotherapy group and the primary surgery group (unadjusted-hazard ratio [HR] 1.19, 95% confidence interval [CI] 0.75-1.89, P = 0.45). Similarly, CSS was comparable between the two groups (unadjusted-HR 1.13, 95%CI 0.68-1.90, P = 0.64). When the types of neoadjuvant chemotherapy regimens were compared, women who received a carboplatin/paclitaxel regimen had better survival outcomes compared to those who received other regimens: PFS, unadjusted-HR 0.38, 95%CI 0.15-0.93, P = 0.027; and CSS, unadjusted-HR 0.21, 95%CI 0.07-0.61, P = 0.002.
Conclusion: Our study found that there is no statistically significant difference in survival between women with stage IV UCS who are tolerated neoadjuvant chemotherapy and those who undergo primary surgery.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Journal of Surgical Oncology, v. 117, issue 3, p. 488-496
Scholar Commons Citation
Matsuo, Koji; Johnson, Marian S.; Im, Dwight D.; Ross, Malcolm S.; Bush, Stephen H.; Yunokawa, Mayu; Blake, Erin A.; Takano, Tadao; Klobocista, Merieme M.; Hasegawa, Kosei; Ueda, Yutaka; Shida, Masako; Baba, Tsukasa; Satoh, Shinya; Yokoyama, Takuhei; Machida, Hiroko; Ikeda, Yuji; Adachi, Sosuke; Miyake, Takahito M.; Iwasaki, Keita; Yanai, Shiori; Takeuchi, Satoshi; Nishimura, Masato; Nagano, Tadayoshi; Takekuma, Munetaka; Shahzad, Mian M.; Pejovic, Tanja; Omatsu, Kohei; Kelley, Joseph L.; Ueland, Frederick R.; and Roman, Lynda D., "Survival Outcome of Women with Stage IV Uterine Carcinosarcoma Who Received Neoadjuvant Chemotherapy Followed by Surgery" (2018). Obstetrics & Gynecology Faculty Publications. 32.
https://digitalcommons.usf.edu/obg_facpub/32
