Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle

Authors

Shijie Song, University of South FloridaFollow
Shuojing Song, Northwestern University
Chuanhai Cao, University of South FloridaFollow
Xiaoyang Lin, University of South FloridaFollow
Kunyu Li, University of South FloridaFollow
Vasyl Sava, University of South FloridaFollow
Juan Sanchez-Ramos, University of South FloridaFollow

Document Type

Article

Publication Date

2013

Digital Object Identifier (DOI)

https://doi.org/10.1155/2013/205878

Abstract

We tested the hypothesis that transient microinjury to the brain elicits cellular and humoral responses that stimulate hippocampal neurogenesis. Brief stereotaxic insertion and removal of a microneedle into the right hippocampus resulted in (a) significantly increased expression of granulocyte-colony stimulating factor (G-CSF), the chemokine MIP-1a, and the proinflammatory cytokine IL12p40; (b) pronounced activation of microglia and astrocytes; and (c) increase in hippocampal neurogenesis. This study describes immediate and early humoral and cellular mechanisms of the brain’s response to microinjury that will be useful for the investigation of potential neuroprotective and deleterious effects of deep brain stimulation in various neuropsychiatric disorders.

Rights Information

This work is licensed under a Creative Commons Attribution 3.0 License.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Stem Cells International, v. 2013, art. 205878

Scholar Commons Citation

Song, Shijie; Song, Shuojing; Cao, Chuanhai; Lin, Xiaoyang; Li, Kunyu; Sava, Vasyl; and Sanchez-Ramos, Juan, "Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle" (2013). Neurology Faculty Publications. 72.
https://digitalcommons.usf.edu/neur_facpub/72