Coenzyme Q10 and Spinocerebellar Ataxias
Document Type
Article
Publication Date
2015
Keywords
coenzyme Q10, statins, spinocerebellar ataxias, neurodegeneration
Digital Object Identifier (DOI)
https://doi.org/10.1002/mds.26088
Abstract
The aim of this study was to investigate the association between drug exposure and disease severity in SCA types 1, 2, 3 and 6. The Clinical Research Consortium for Spinocerebellar Ataxias (CRC-SCA) enrolled 319 participants with SCA1, 2, 3, and 6 from 12 medical centers in the United States and repeatedly measured clinical severity by the Scale for Assessment and Rating of Ataxia (SARA), the Unified Huntington's Disease Rating Scale part IV (UHDRS-IV), and the 9-item Patient Health Questionnaire during July 2009 to May 2012. We employed generalized estimating equations in regression models to study the longitudinal effects of coenzyme Q10 (CoQ10), statin, and vitamin E on clinical severity of ataxia after adjusting for age, sex, and pathological CAG repeat number. Cross-sectionally, exposure to CoQ10 was associated with lower SARA and higher UHDRS-IV scores in SCA1 and 3. No association was found between statins, vitamin E, and clinical outcome. Longitudinally, CoQ10, statins, and vitamin E did not change the rates of clinical deterioration indexed by SARA and UHDRS-IV scores within 2 years. CoQ10 is associated with better clinical outcome in SCA1 and 3. These drug exposures did not appear to influence clinical progression within 2 years. Further studies are warranted to confirm the association. © 2014 International Parkinson and Movement Disorder Society
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Movement Disorders, v. 30, issue 2, p. 214-220
Scholar Commons Citation
Lo, Raymond Y.; Figueroa, Karla P.; Pulst, Stefan M.; Lin, Chi-Ying; Perlman, Susan; Wilmot, George; Gomez, Christopher; Schmahmann, Jeremy; Paulson, Henry; Shakkottai, Vikram G.; Ying, Sarah; Zesiewicz, Theresa; Bushara, Khalaf; Geschwind, Michael; Xia, Guangbin; Subramony, S.H.; Ashizawa, Tetsuo; and Kuo, Sheng-Han, "Coenzyme Q10 and Spinocerebellar Ataxias" (2015). Neurology Faculty Publications. 108.
https://digitalcommons.usf.edu/neur_facpub/108
