Mannitol-Enhanced Delivery of Stem Cells and Their Growth Factors across the Blood–Brain Barrier
Document Type
Article
Publication Date
2014
Keywords
Mannitol, Stem cells, Blood–brain barrier permeability, Neurotrophic factors, Cerebral ischemia, Adult, Neonates
Digital Object Identifier (DOI)
https://doi.org/10.3727/096368914X678337
Abstract
Ischemic brain injury in adults and neonates is a significant clinical problem with limited therapeutic interventions. Currently, clinicians have only tPA available for stroke treatment and hypothermia for cerebral palsy. Owing to the lack of treatment options, there is a need for novel treatments such as stem cell therapy. Various stem cells including cells from embryo, fetus, perinatal, and adult tissues have proved effective in preclinical and small clinical trials. However, a limiting factor in the success of these treatments is the delivery of the cells and their by-products (neurotrophic factors) into the injured brain. We have demonstrated that mannitol, a drug with the potential to transiently open the blood–brain barrier and facilitate the entry of stem cells and trophic factors, as a solution to the delivery problem. The combination of stem cell therapy and mannitol may improve therapeutic outcomes in adult stroke and neonatal cerebral palsy.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Cell Transplantation, v. 23, issue 4-5, p. 531-539
Scholar Commons Citation
Gonzales-Portillo, Gabriel S.; Sanberg, Paul R.; Franzblau, Max; Gonzales-Portillo, Chiara; Diamandis, Theo; Staples, Meaghan; Sanberg, Cyndy D.; and Borlongan, Cesar V., "Mannitol-Enhanced Delivery of Stem Cells and Their Growth Factors across the Blood–Brain Barrier" (2014). Neurosurgery and Brain Repair Faculty Publications. 62.
https://digitalcommons.usf.edu/nbr_facpub/62
