May the force be with you: Transfer of healthy mitochondria from stem cells to stroke cells
Document Type
Article
Publication Date
2018
Keywords
Cerebral ischemia, energy metabolism, cellular bioenergetics, transplantation, inflammation, regenerative medicine
Digital Object Identifier (DOI)
https://doi.org/10.1177/0271678X18811277
Abstract
Stroke is a major cause of death and disability in the United States and around the world with limited therapeutic option. Here, we discuss the critical role of mitochondria in stem cell-mediated rescue of stroke brain by highlighting the concept that deleting the mitochondria from stem cells abolishes the cells’ regenerative potency. The application of innovative approaches entailing generation of mitochondria-voided stem cells as well as pharmacological inhibition of mitochondrial function may elucidate the mechanism underlying transfer of healthy mitochondria to ischemic cells, thereby providing key insights in the pathology and treatment of stroke and other brain disorders plagued with mitochondrial dysfunctions.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Journal of Cerebral Blood Flow & Metabolism, v. 39, issue 2, p. 367-370
Scholar Commons Citation
Borlongan, Cesar V.; Nguyen, Hung; Lippert, Trenton; Russo, Eleonora; Tuazon, Julian; Xu, Kaya; Lee, Jea-Young; Sanberg, Paul R.; Kaneko, Yuji; and Napoli, Eleonora, "May the force be with you: Transfer of healthy mitochondria from stem cells to stroke cells" (2018). Neurosurgery and Brain Repair Faculty Publications. 56.
https://digitalcommons.usf.edu/nbr_facpub/56
