Document Type
Article
Publication Date
2020
Keywords
cell therapy, iPS cells, Parkinson's disease, stroke, traumatic brain injury
Digital Object Identifier (DOI)
https://doi.org/10.1111/cns.13247
Abstract
Cell therapy for disorders of the central nervous system has progressed to a new level of clinical application. Various clinical studies are underway for Parkinson's disease, stroke, traumatic brain injury, and various other neurological diseases. Recent biotechnological developments in cell therapy have taken advantage of the technology of induced pluripotent stem (iPS) cells. The advent of iPS cells has provided a robust stem cell donor source for neurorestoration via transplantation. Additionally, iPS cells have served as a platform for the discovery of therapeutics drugs, allowing breakthroughs in our understanding of the pathology and treatment of neurological diseases. Despite these recent advances in iPS, adult tissue-derived mesenchymal stem cells remain the widely used donor for cell transplantation. Mesenchymal stem cells are easily isolated and amplified toward the cells' unique trophic factor-secretion property. In this review article, the milestone achievements of cell therapy for central nervous system disorders, with equal consideration on the present translational obstacles for clinic application, are described.
Rights Information
This work is licensed under a Creative Commons Attribution 4.0 License.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
CNS Neuroscience & Therapeautics, v. 26, issue 6, p. 595-602
Scholar Commons Citation
Yasuhara, Takao; Kawauchi, Satoshi; Kin, Kyohei; Morimoto, Jun; Kameda, Masahiro; Sasaki, Tatsuya; Bonsack, Brooke; Kingsbury, Chase; Tajiri, Naoki; Borlongan, Cesar V.; and Date, Isao, "Cell Therapy for Central Nervous System Disorders: Current Obstacles to Progress" (2020). Neurosurgery and Brain Repair Faculty Publications. 35.
https://digitalcommons.usf.edu/nbr_facpub/35
