Emergence of Unique SARS-CoV-2 ORF10 Variants and Their Impact on Protein Structure and Function
SARS-CoV-2, ORF10, Co-occurring mutations, Intrinsic protein disorder, And ubiquitin ligase complex
Digital Object Identifier (DOI)
The devastating impact of the ongoing coronavirus disease 2019 (COVID-19) on public health, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has made targeting the COVID-19 pandemic a top priority in medical research and pharmaceutical development. Surveillance of SARS-CoV-2 mutations is essential for the comprehension of SARS-CoV-2 variant diversity and their impact on virulence and pathogenicity. The SARS-CoV-2 open reading frame 10 (ORF10) protein interacts with multiple human proteins CUL2, ELOB, ELOC, MAP7D1, PPT1, RBX1, THTPA, TIMM8B, and ZYG11B expressed in lung tissue. Mutations and co-occurring mutations in the emerging SARS-CoV-2 ORF10 variants are expected to impact the severity of the virus and its associated consequences. In this article, we highlight 128 single mutations and 35 co-occurring mutations in the unique SARS-CoV-2 ORF10 variants. The possible predicted effects of these mutations and co-occurring mutations on the secondary structure of ORF10 variants and host protein interactomes are presented. The findings highlight the possible effects of mutations and co-occurring mutations on the emerging 140 ORF10 unique variants from secondary structure and intrinsic protein disorder perspectives.
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Citation / Publisher Attribution
International Journal of Biological Macromolecules, v. 194, p. 128-143
Scholar Commons Citation
Hassan, Sk. Sarif; Lundstrom, Kenneth; Serrano-Aroca, Ángel; Adadi, Parise; Aljabali, Alaa A.A.; Redwan, Elrashdy M.; Lal, Amos; Kandimalla, Ramesh; El-Aziz, Tarek Mohamed; Pal Choudhury, Pabitra; Azad, Gajendra Kumar; Sherchan, Samendra P.; Chauhan, Gaurav; Tambuwala, Murtaza; Takayama, Kazuo; Barh, Debmalya; Palu, Giorgio; Basu, Pallab; and Uversky, Vladimir N., "Emergence of Unique SARS-CoV-2 ORF10 Variants and Their Impact on Protein Structure and Function" (2022). Molecular Medicine Faculty Publications. 990.