Concerted Action of Metals and Macromolecular Crowding on The Fibrillation of α-synuclein

Document Type


Publication Date



Parkinson's Disease, α-synuclein, Crowding, Fibrillation, Aggregation, Metals

Digital Object Identifier (DOI)


Certain metals lead to increased risk of Parkinsons disease (PD) and the aggregation of α-synuclein is implicated in the PD pathology. Although α-synuclein fibrillation has been extensively studied in dilute solutions in vitro, the intracellular environment is highly crowded. We are showing here that certain metals cause a significant acceleration of α-synuclein fibrillation in the presence of high concentrations of various macromolecules mostly through decreasing the fibrillation lagtime. The faster fibrillation in crowded environments in the presence of heavy metals suggests a simple molecular basis for the observed elevated risk of PD due to exposure to metals.

Was this content written or created while at USF?


Citation / Publisher Attribution

Protein & Peptide Letters, v. 15, issue 10, p. 1079-1085