Concerted Action of Metals and Macromolecular Crowding on The Fibrillation of α-synuclein
Parkinson's Disease, α-synuclein, Crowding, Fibrillation, Aggregation, Metals
Digital Object Identifier (DOI)
Certain metals lead to increased risk of Parkinsons disease (PD) and the aggregation of α-synuclein is implicated in the PD pathology. Although α-synuclein fibrillation has been extensively studied in dilute solutions in vitro, the intracellular environment is highly crowded. We are showing here that certain metals cause a significant acceleration of α-synuclein fibrillation in the presence of high concentrations of various macromolecules mostly through decreasing the fibrillation lagtime. The faster fibrillation in crowded environments in the presence of heavy metals suggests a simple molecular basis for the observed elevated risk of PD due to exposure to metals.
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Citation / Publisher Attribution
Protein & Peptide Letters, v. 15, issue 10, p. 1079-1085
Scholar Commons Citation
Munishkina, Larissa A.; Fink, Anthony L.; and Uversky, Vladimir N., "Concerted Action of Metals and Macromolecular Crowding on The Fibrillation of α-synuclein" (2008). Molecular Medicine Faculty Publications. 811.