The Triple Power of D³: Protein Intrinsic Disorder in Degenerative Diseases

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Neurodegenerative Disease, Intrinsically Disordered, Protein Protein Folding, Protein Misfolding, Protein Aggregation, Protein-protein Interaction, Proteinfunction, Protein Dysfunction

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This review is an update of an article published four years ago (Uversky V.N. (2009) Intrinsically disordered proteins in neurodegenerative diseases: another illustration of the D² concept. Frontiers in Bioscience 14, 5188-5238). The major goal of this review is to show the interconnections between intrinsically disordered proteins (IDPs) and human neurodegeneration. This brings to existence a new D³ concept: protein intrinsic Disorder in neuroDegenerative Diseases. An important aspect of the D³ concept is that it deals with three D³'s, emphasizing that intrinsically Disordered proteins are abundantly found in various neuroDegenerative Diseases (the first D³), that these IDPs provoke neuroDegeneration due to their Dysfunctionality (the second D³), and that neuroDegeneration-related IDPs are often controlled by other Disordered proteins (the third D³).

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Citation / Publisher Attribution

Frontiers in Bioscience-Landmark, v. 19, issue 2, p. 181-258