Intrinsically Disordered Proteins from A to Z

Document Type


Publication Date



Intrinsically Disordered Proteins, Protein–protein Interaction, Protein Structure, Protein Function, Protein Non-folding

Digital Object Identifier (DOI)


The ideas that proteins might possess specific functions without being uniquely folded into rigid 3D-structures and that these floppy polypeptides might constitute a noticeable part of any given proteome would have been considered as a preposterous fiction 15 or even 10 years ago. The situation has changed recently, and the existence of functional yet intrinsically disordered proteins and regions has become accepted by a significant number of protein scientists. These fuzzy objects with fuzzy structures and fuzzy functions are among the most interesting and attractive targets for modern protein research. This review summarizes some of the major discoveries and breakthroughs in the field of intrinsic disorder by representing related concepts and definitions.

Was this content written or created while at USF?


Citation / Publisher Attribution

The International Journal of Biochemistry & Cell Biology, v. 43, issue 8, p. 1090-1103