Intrinsic Disorder in Biomarkers of Insulin Resistance, Hypoadiponectinemia, and Endothelial Dysfunction Among the Type 2 Diabetic Patients
Adiponectin, Intrinsically disordered protein, Insulin resistance, vCAM-1, E-selectin, Type 2 Diabetes, Obesity, iCAM-1
Digital Object Identifier (DOI)
Type 2 diabetes mellitus (T2DM) is a chronic and progressive disease that is strongly associated with the all-cause and cardiovascular mortality. The present study aimed to analyze the abundance and functionality of intrinsically disordered regions in several biomarkers of insulin resistance, adiponectin, and endothelial dysfunction found in the T2DM patients. In fact, in comparison to controls, obese T2DM patients are known to have significantly higher levels of inter-cellular adhesion molecule (iCAM-1), vascular cell adhesion molecule (vCAM-1), and E-selectin, whereas their adiponectin levels are relatively low. Bioinformatics analysis revealed that these selected biomarkers (iCAM-1, vCAM-1, E-selectin, and adiponectin) are characterized by the noticeable levels of intrinsic disorder propensity and high binding promiscuity, which are important features expected for proteins serving as biomarkers. Within the limit of studied groups, there is an association between insulin resistance and both hypoadiponectinemia and endothelial dysfunction.
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Citation / Publisher Attribution
PeerJ, v. 3, art. e1395v1
Scholar Commons Citation
Jiffri, Osama H.; Al-Sharif, Fadwa M.; Jiffri, Essam H.; and Uversky, Vladimir N., "Intrinsic Disorder in Biomarkers of Insulin Resistance, Hypoadiponectinemia, and Endothelial Dysfunction Among the Type 2 Diabetic Patients" (2015). Molecular Medicine Faculty Publications. 43.