Amino Acid/Water Interactions Study: A New Amino Acid Scale
Amino Acids, Descriptors, Protein Structure, Aqueous Two-Phase Partitioning, Biological Activity.
Digital Object Identifier (DOI)
Partition ratios of 8 free l-amino acids (Gln, Glu, His, Lys, Met, Ser, Thr, and Tyr) were measured in 10 different polymer/polymer aqueous two-phase systems containing 0.15 M NaCl in 0.01 M phosphate buffer, pH 7.4. The solute-specific coefficients representing the solute dipole/dipole, hydrogen-bonding and electrostatic interactions with the aqueous environment of the amino acids were determined by multiple linear regression analysis using a modified linear solvation energy relationship. The solute-specific coefficients determined in this study together with the solute-specific coefficients reported previously for amino acids with non-polar side-chains where used in a Quantitative Structure/Property Relationship analysis. It is shown that linear combinations of these solute-specific coefficients are correlated well with various physicochemical, structural, and biological properties of amino acids.
Was this content written or created while at USF?
Citation / Publisher Attribution
Journal of Biomolecular Structure and Dynamics, v. 32, issue 6, p. 959-968
Scholar Commons Citation
Madeira, Pedro P.; Bessa, Ana; Álvares-Ribeiro, Luís; Aires-Barros, M. Raquel; Rodrigues, Alírio E.; Uversky, Vladimir N.; and Zaslavsky, Boris Y., "Amino Acid/Water Interactions Study: A New Amino Acid Scale" (2014). Molecular Medicine Faculty Publications. 422.