Intrinsically Disordered Proteins: Targets for the Future?
Document Type
Book Chapter
Publication Date
2020
Keywords
Disorder-based Rational Drug Design KW, Intrinsically Disordered Protein Regions, Intrinsically Disordered Proteins, Ligands, Novel Drug Targets, Protein Deposition Diseases, Rational Drug Design
Digital Object Identifier (DOI)
https://doi.org/10.1002/9781118681121.ch25
Abstract
Various studies have revealed that important biological functions of many proteins do not require stable well-defined structure in solution, with many functions originating from the lack of ordered structure in a protein molecule. These intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs) exist as structural ensembles either at the secondary or at the tertiary structure level. This chapter presents the currently available strategies for effective inhibition of disorder-based protein interactions. While ligands and their interactions with targets will remain the focus of any structure-based approach to drug design, the requirements for both targets and crystals may change. Several approaches based on principally different molecular mechanisms can be used for the development of drugs affecting functions of IDPs. The chapter discusses order-based and disorder-based rational drug design. It also shows that small molecules for fighting IDP-based protein deposition diseases can be found.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Intrinsically Disordered Proteins: Targets for the Future?, in J. -P. Renaud (Ed.), Structural Biology in Drug Discovery: Methods, Techniques, and Practices, John Wiley & Sons, p. 587-612
Scholar Commons Citation
Uversky, Vladimir N., "Intrinsically Disordered Proteins: Targets for the Future?" (2020). Molecular Medicine Faculty Publications. 1149.
https://digitalcommons.usf.edu/mme_facpub/1149
