Liquid–liquid Phase Separation and Biomolecular Condensates in Cell Quiescence
Document Type
Book Chapter
Publication Date
2020
Keywords
Biochemical Mechanism, Biophysical Chemistry, Cell, Cell Structure, Cellular Process, Functional Aspects of Cell Biology, Intrinsically Disordered Region, Liquid–liquid Phase Separation, Membrane-less Organelles, Molecular Biology, Stem Cells Research
Digital Object Identifier (DOI)
https://doi.org/10.1016/B978-0-12-823967-4.00001-4
Abstract
Quiescence or a state of reversible growth arrest, where cells are noncycling but able to proliferate in response to extrinsic stimuli, helps stem cell to maintain their stemness, protects their key functional features, preserves genomic integrity over a lifetime, and ensures their function during tissue repair in the event of an injury and tissue homeostasis. In general, the transition to the quiescent state represents cellular response to the environmental stress: this survival mechanism is switched on, when growth is not supported by the environment. Furthermore, subpopulations of tumor cells can enter dormant states, where they can persist through drug treatments, causing relapses in disease and, upon reactivation, can trigger metastatic disease. Quiescence requires tight control at each stage: i.e., entry into, maintenance of, and exist from this state. Although quiescence can happen in different cells and different organisms, each with own complex regulatory mechanisms, there is an interesting twist indicating involvement of liquid–liquid phase separation (LLPS) and biomolecular condensates in quiescence regulation. This chapter considers some of the illustrative examples of the utilization of LLPS and biomolecular condensates in the quiescent cells.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Liquid–liquid Phase Separation and Biomolecular Condensates in Cell Quiescence, in V. N. Uversky (Ed.), Droplets of Life, Academic Press, p. 157-172
Scholar Commons Citation
Uversky, Vladimir N, "Liquid–liquid Phase Separation and Biomolecular Condensates in Cell Quiescence" (2020). Molecular Medicine Faculty Publications. 1131.
https://digitalcommons.usf.edu/mme_facpub/1131
