MLOstasis: Liquid–liquid Phase Separation and Biomolecular Condensates in Cell Competition, Fitness, and Aging
Document Type
Book Chapter
Publication Date
2023
Keywords
Cell Competition, Cell Fitness, Cell Signaling, Cellular Process, Cellular Senescence, Cellular Aging, Molecular Biology, Molecular Network, Pathological Process
Digital Object Identifier (DOI)
https://doi.org/10.1016/B978-0-12-823967-4.00013-0
Abstract
Cell fitness, i.e., the ability of a cell to persevere under specific conditions, represents an important factor driving cell competition, which, in its turn, is at the roots of numerous biological processes, including aging. These biological phenomena encompass a multitude of extremely complex and highly intertwined processes and pathways and are undoubtedly crucial for the maintenance of life. This chapter represents several illustrative examples showing the importance of liquid–liquid phase separation and resulting membrane-less organelles (MLOs) and biomolecular condensates in regulation of cell fitness, cell competition, and aging/senescence. It also introduces a concept of MLOstasis (MLO homeostasis), which represents a multitude of cellular pathways and processes defining and controlling the fate of and interplay between the multiple MLOs and also includes pathways and processes via which MLOs affect and regulate cellular fitness.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
MLOstasis: Liquid–liquid Phase Separation and Biomolecular Condensates in Cell Competition, Fitness, and Aging, in V. N. Uversky (Ed.), Droplets of Life, Academic Press, p. 485-504
Scholar Commons Citation
Uversky, Vladimir N., "MLOstasis: Liquid–liquid Phase Separation and Biomolecular Condensates in Cell Competition, Fitness, and Aging" (2023). Molecular Medicine Faculty Publications. 1127.
https://digitalcommons.usf.edu/mme_facpub/1127
