Macromolecular Crowding: How It Affects Protein Structure, Disorder, and Catalysis
Document Type
Book Chapter
Publication Date
2023
Keywords
Amyloids, Excluded Volume, Glycoprotein Processing, Macromolecular Crowding Agents, Preferential Interaction, Protein Aggregation, Protein Assembly
Digital Object Identifier (DOI)
https://doi.org/10.1016/B978-0-323-99533-7.00016-9
Abstract
While much of classical enzymology has been developed based on the dilute aqueous solutions of purified enzymes, intracellular environments are nonideal and represent a rather crowded milieu. This chapter is a brief overview of how these crowded conditions can impact both structured and disordered proteins. An important aspect is the effect of macromolecular crowding on protein catalytic activities.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Macromolecular Crowding: How It Affects Protein Structure, Disorder, and Catalysis, in M. N. Gupta & V. N. Uversky (Eds.), Structure and Intrinsic Disorder in Enzymology, Academic Press, p. 353-376
Scholar Commons Citation
Gupta, Munishwar Nath and Uversky, Vladimir N, "Macromolecular Crowding: How It Affects Protein Structure, Disorder, and Catalysis" (2023). Molecular Medicine Faculty Publications. 1116.
https://digitalcommons.usf.edu/mme_facpub/1116
