Intrinsic Disorder in Proteins Associated with Neurodegenerative Diseases

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Book Chapter

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Multiple System Atrophy, Dementia With Lewy Body, Spinal Muscular Atrophy, Prion Disease, Intrinsic Disorder

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Neurodegenerative diseases constitute a set of pathological conditions originating from the slow, irreversible and systemic cell loss within the various regions of the brain and/or the spinal cord. Depending on the affected region, the outcomes of the neurodegeneration are very broad, starting from the problems with movements and ending with dementia. Neurodegenerative diseases are proteinopathies associated with misbehavior and disarrangement of a specific protein, affecting its processing, functioning, and/or folding. Many proteins associated with human neurodegenerative diseases are intrinsically disordered; i.e., they lack stable tertiary and/or secondary structure under physiological conditions in vitro. The major goal of this chapter is to uncover intriguing interconnections between intrinsic disorder and human neurodegenerative diseases.

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Citation / Publisher Attribution

Intrinsic Disorder in Proteins Associated with Neurodegenerative Diseases, in J. Ovádi & F. Orosz (Eds.), Protein Folding and Misfolding: Neurodegenerative Diseases, Springer, p. 21-75