Baroenzymology, Cryoenzymology, Intrinsically Disordered Proteins, Macromolecular Crowding, Nanomaterials, Partially Folded Intermediate, Protein Engineering, Protein Flexibility, Protein Folding, Protein Structure
Digital Object Identifier (DOI)
Transitions between the unfolded and native states of the ordered globular proteins are accompanied by the accumulation of several intermediates, such as pre-molten globules, wet molten globules, and dry molten globules. Structurally equivalent conformations can serve as native functional states of intrinsically disordered proteins. This overview captures the characteristics and importance of these molten globules in both structured and intrinsically disordered proteins. It also discusses examples of engineered molten globules. The formation of these intermediates under conditions of macromolecular crowding and their interactions with nanomaterials are also reviewed.
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Citation / Publisher Attribution
International Journal of Molecular Sciences, v. 24, issue 3, art. 2424
Scholar Commons Citation
Gupta, Munishwar Nath and Uversky, Vladimir N., "Pre-Molten, Wet, and Dry Molten Globules en Route to the Functional State of Proteins" (2023). Molecular Medicine Faculty Publications. 1031.