The Importance of Accessory Protein Variants in the Pathogenicity of SARS-CoV-2


Sk. Sarif Hassan, Department of Mathematics, Pingla Thana Mahavidyalaya, Maligram, 721140, India
Pabitra Pal Choudhury, Indian Statistical Institute
Guy W. Dayhoff, University of South Florida
Alaa A.A. Aljabali, Yarmouk University-Faculty of Pharmacy
Bruce D. Uhal, Michigan State University
Kenneth Lundstrom, PanTherapeutics, Rte de Lavaux 49, CH1095, Lutry, Switzerland
Nima Rezaei, Tehran University of Medical Sciences
Damiano Pizzol, Italian Agency for Development Cooperation - Khartoum, Sudan Street 33, Al Amarat, Sudan
Parise Adadi, University of Otago
Amos Lal, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA
Antonio Soares, University of Texas Health Science Center at San Antonio
Tarek Mohamed Abd El-Aziz, University of Texas Health Science Center at San Antonio
Adam M. Brufsky, University of Pittsburgh School of Medicine
Gajendra Kumar Azad, Patna University
Samendra P. Sherchan, Tulane University
Wagner Baetas-da-Cruz, Federal University of Rio de Janeiro (UFRJ)
Kazuo Takayama, Kyoto University
Ãngel Serrano-Aroca, Catholic University of Valencia San Vicente M'artir
Gaurav Chauhan, School of Engineering and Sciences, Tecnologico de Monterrey, Av. Eugenio Garza Sada 2501 Sur, 64849, Monterrey, Nuevo León, Mexico
Giorgio Palu, University of Padova
Yogendra Kumar Mishra, University of Southern Denmark
Debmalya Barh, Institute of Integrative Omics and Applied Biotechnology (IIOAB)
Raner Jośe Santana Silva, Departamento de Ciencias Biologicas (DCB), Programa de Pos-Graduacao em Genetica e Biologia Molecular (PPGGBM), Universidade Estadual de Santa Cruz (UESC), Rodovia Ilheus-Itabuna, km 16, 45662-900, Ilheus, BA, Brazil
Bruno Silva Andrade, Laboratório de Bioinformática e Química Computacional, Departamento de Ciências Biológicas, Universidade Estadual do Sudoeste da Bahia (UESB), Jequié, 45206-190, Brazil
Vasco Azevedo, Departamento de Genética, Ecologia e Evolucao, Instituto de Cîencias Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Aristóteles Góes-Neto, Laboratório de Biologia Molecular e Computacional de Fungos, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil
Nicolas G. Bazan, Neuroscience Center of Excellence, School of Medicine, LSU Health New Orleans, New Orleans, LA, 70112, USA
Elrashdy M. Redwan, King Abdulaz University
Murtaza Tambuwala, Ulster University
Vladimir N. Uversky, University of South FloridaFollow

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ORF3a, ORF6, ORF7a, ORF7b, ORF8, ORF10, Pathogenicity, SARS-CoV-2

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The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune mechanisms. These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines such as interleukin 1β (IL-1β) and are critical in COVID-19 pathology. Outspread variations of each of the six accessory proteins were observed across six continents of all complete SARS-CoV-2 proteomes based on the data reported before November 2020. A decreasing order of percentage of unique variations in the accessory proteins was determined as ORF3a > ORF8 > ORF7a > ORF6 > ORF10 > ORF7b across all continents. The highest and lowest unique variations of ORF3a were observed in South America and Oceania, respectively. These findings suggest that the wide variations in accessory proteins seem to affect the pathogenicity of SARS-CoV-2.

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Citation / Publisher Attribution

Archives of Biochemistry and Biophysics, v. 717, art. 109124