Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity
Alternative Title
Science
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Publication Date
1-25-2013
Volume Number
339
Issue Number
6118
Abstract
Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related species, fruit bat Pteropus alecto and insectivorous bat Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor κB pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.
Document Type
Article
Digital Object Identifier (DOI)
https://doi.org/10.1126/science.1230835
Recommended Citation
Zhang, Guojie; Cowled, Christopher; and Shi, Zhengli, "Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity" (2013). KIP Articles. 6340.
https://digitalcommons.usf.edu/kip_articles/6340
