Document Type

Article

Publication Date

6-12-2009

Keywords

Aging, Inflammation, Lipid, Oxidative stress, Redox balance, Sarcopenia

Digital Object Identifier (DOI)

https://doi.org/10.1016/j.bbrc.2009.04.071

Abstract

In this study, we examined the effect of CLA isomers in preventing age-associated muscle loss and the mechanisms underlying this effect, using 12-months-old C57BL/6 mice fed 10% corn oil (CO) or a diet supplemented with 0.5% c9t11-CLA, t10c12-CLA, or c9t11-CLA+t10c12-CLA (CLA-mix) for 6 months. Both t10c12-CLA and CLA-mix groups showed significantly higher muscle mass, as compared to CO and c9t11-CLA groups, measured by dual-energy X-ray absorptiometry and muscle wet weight. Enhanced mitochondrial ATP production, with higher membrane potential, and elevated muscle antioxidant enzymes (catalase and glutathione peroxidase) production, accompanied by slight increase in H2O2 production was noted in t10c12-CLA and CLA-mix groups, as compared to that of CO and c9t11-CLA groups. Oxidative stress, as measured by serum malondialdehyde and inflammation, as measured by LPS-treated splenocyte IL-6 and TNF-α, were significantly less in CLA isomers groups. Thus, CLA may be a novel dietary supplement that will prevent sarcopenia by maintaining redox balance during aging.

Was this content written or created while at USF?

No

Citation / Publisher Attribution

Biochemical and Biophysical Research Communications, v. 383, issue 4, p. 513-518

This article is the post-print author version. Final version available at: https://doi.org/10.1016/j.bbrc.2009.04.071

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