Mathematical Modeling of Macrophage Activation in Left Ventricular Remodeling Post-Myocardial Infarction

Authors

Yunji Wang, University of Texas at San Antonio
Yufang Jin, University of Texas at San Antonio
Yonggang Ma, University of Texas Health Science Center at San Antonio
Ganesh V. Halade, University of Texas Health Science Center at San AntonioFollow
Merry L. Linsey, University of Texas Health Science Center at San Antonio

Document Type

Conference Proceeding

Publication Date

1-1-2011

Digital Object Identifier (DOI)

https://doi.org/10.1109/gensips.2011.6169480

Abstract

The macrophage plays a key role in regulating the remodeling of the left ventricle (LV) post-myocardial infarction (MI). However, the underlying regulatory mechanisms of macrophage activations were understudied. The goal of this study, therefore, was to establish a framework for macrophage activations and build a mathematical model based on the framework by integrating computational and experimental approaches. Accordingly, we established a framework including myocytes, monocytes, macrophages, and interlukin-1 (IL-1), IL-10, and tumor necrosis-alpha (TNF-α) based on literature, established a set of ordinary differential equations as the mathematical model, and primarily validated the model with experimental results. This study provides a useful tool to further study macrophage activations.

Was this content written or created while at USF?

No

Citation / Publisher Attribution

Mathematical Modeling of Macrophage Activation in Left Ventricular Remodeling Post-Myocardial Infarction, 2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS), San Antonio, TX, 2011, p. 202-205

Scholar Commons Citation

Wang, Yunji; Jin, Yufang; Ma, Yonggang; Halade, Ganesh V.; and Linsey, Merry L., "Mathematical Modeling of Macrophage Activation in Left Ventricular Remodeling Post-Myocardial Infarction" (2011). Internal Medicine Faculty Publications. 72.
https://digitalcommons.usf.edu/intmed_facpub/72