Document Type
Article
Publication Date
4-1-2011
Keywords
Aging, Cardiac remodeling, Corn oil, Fish oil, Inflammation, Left ventricle hypertrophy, Rosiglitazone
Digital Object Identifier (DOI)
https://doi.org/10.1016/j.phrs.2010.12.012
Abstract
Clinical studies suggest that rosiglitazone (RSG) treatment may increase the incidence of heart failure in diabetic patients. In this study, we examined whether a high corn oil diet with RSG treatment in insulin resistant aging mice exerted metabolic and pro-inflammatory effects that stimulate cardiac dysfunction. We also evaluated whether fish oil attenuated these effects. Female C57BL/6J mice (13 months old) were divided into 5 groups: (1) lean control (LC), (2) corn oil, (3) fish oil, (4) corn oil + RSG and (5) fish oil + RSG. Mice fed a corn oil enriched diet and RSG developed hypertrophy of the left ventricle (LV) and decreased fractional shortening, despite a significant increase in total body lean mass. In contrast, LV hypertrophy was prevented in RSG treated mice fed a fish oil enriched diet. Importantly, hyperglycemia was controlled in both RSG groups. Further, fish oil + RSG decreased LV expression of atrial and brain natriuretic peptides, fibronectin and the pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α, concomitant with increased interleukin-10 and adiponectin levels compared to the corn oil + RSG group. Fish oil + RSG treatment suppressed inflammation, increased serum adiponectin, and improved fractional shortening, attenuating the cardiac remodeling seen in the corn oil + RSG diet fed C57BL/6J insulin resistant aging mice. Our results suggest that RSG treatment has context-dependent effects on cardiac remodeling and serves a negative cardiac role when given with a corn oil enriched diet.
Rights Information
Was this content written or created while at USF?
No
Citation / Publisher Attribution
Pharmacological Research, v. 63, issue 4, p. 300-307
This article is the post-print author version. Final version available at: https://doi.org/10.1016/j.phrs.2010.12.012
Scholar Commons Citation
Halade, Ganesh V.; Williams, Paul J.; Lindsey, Merry L.; and Fernandes, Gabriel, "Fish Oil Decreases Inflammation and Reduces Cardiac Remodeling in Rosiglitazone Treated Aging Mice" (2011). Internal Medicine Faculty Publications. 71.
https://digitalcommons.usf.edu/intmed_facpub/71
