Specialized Pro-Resolving Mediators Directs Cardiac Healing and Repair with Activation of Inflammation and Resolution Program in Heart Failure

Document Type

Book Chapter

Publication Date

1-1-2019

Keywords

Cardiac repair, Heart failure, Leukocytes, Myocardial infarction, Resolution of inflammation, Specialized pro-resolving mediators

Digital Object Identifier (DOI)

https://doi.org/10.1007/978-3-030-21735-8_6

Abstract

After myocardial infarction, splenic leukocytes direct biosynthesis of specialized pro-resolving mediators (SPMs) that are essential for the resolution of inflammation and tissue repair. In a laboratory environment, after coronary ligation of healthy risk free rodents (young adult mice) leukocytes biosynthesize SPMs with induced activity of lipoxygenases and cyclooxygenases, which facilitate cardiac repair. Activated monocytes/macrophages drive the biosynthesis of SPMs following experimental myocardial infarction in mice during the acute heart failure. In the presented review, we provided the recent updates on SPMs (resolvins, lipoxins and maresins) in cardiac repair that may serve as novel therapeutics for future heart failure therapy/management. We incorporated the underlying causes of non-resolving inflammation following cardiac injury if superimposed with obesity, hypertension, diabetes, disrupted circadian rhythm, co-medication (painkillers or oncological therapeutics), and/or aging that may delay or impair the biosynthesis of SPMs, intensifying pathological remodeling in heart failure.

Was this content written or created while at USF?

No

Citation / Publisher Attribution

Specialized Pro-Resolving Mediators Directs Cardiac Healing and Repair with Activation of Inflammation and Resolution Program in Heart Failure, in K. Honn & D. Zeldin (Eds.), The Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases. Advances in Experimental Medicine and Biology, Springer, v. 1161, p. 45-64

Link to Full Text

Share

COinS