Document Type
Article
Publication Date
2018
Digital Object Identifier (DOI)
https://doi.org/10.1155/2018/9191582
Abstract
Nonhepatosplenic/noncutaneous γδ peripheral T-cell lymphoma (NHNCγδ PTCL) represents a miscellaneous group of unrelated T-cell lymphomas of which only isolated cases have been reported. We describe two cases of transformation from T-lymphoblastic leukemia/lymphoma to NHNCγδ PTCL. Transformation into more aggressive disease is a rare event in T-cell lineage-derived hematologic malignancies compared to B-cell neoplasms. Nevertheless, both of our cases involved relapse as PTCL manifested with skin involvement and an overt shift from blastic morphology to large granular leukemia-like mature T cells. Among other notable molecular characteristics, expression of immature markers such as TdT was lost in both cases. Based on cytogenetics, phenotype, and morphology, both patients represent a novel phenomenon of clonal transformation from T-ALL to PTCL which has rarely been reported in the literature. Such transformation may carry important diagnostic and biological implications.
Rights Information
This work is licensed under a Creative Commons Attribution 4.0 License.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Case Reports in Hematology, v. 2018, art. 9191582
Scholar Commons Citation
Markow, Michael; Mirza, Abu-Sayeef; Perez, Lia; Shao, Haipeng; Horna, Pedro; Anasetti, Claudio; Sokol, Lubomir; and Hussaini, Mohammad O., "Transformation of T-Cell Acute Lymphoblastic Lymphoma to Peripheral T-Cell Lymphoma: A Report of Two Cases" (2018). Internal Medicine Faculty Publications. 123.
https://digitalcommons.usf.edu/intmed_facpub/123
