Document Type
Article
Publication Date
2015
Keywords
alternatives, doxycycline, minocycline, shortage, substitution
Digital Object Identifier (DOI)
https://doi.org/10.1093/ofid/ofv178
Abstract
Doxycycline, a commonly prescribed tetracycline, remains on intermittent shortage. We systematically reviewed the literature to assess minocycline as an alternative to doxycycline in select conditions, given doxycycline's continued shortage. We identified 19 studies, 10 of which were published before 2000. Thirteen of the studies were prospective, but only 1 of these studies was randomized. Based on the available data, we found minocycline to be a reasonable substitute for doxycycline in the following scenarios: skin and soft-tissue infections and outpatient treatment of community-acquired pneumonia in young, otherwise healthy patients or in patients with macrolide-resistant Mycoplasma pneumoniae, as well as Lyme disease prophylaxis and select rickettsial disease should doxycycline be unavailable.
Rights Information
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
Open Forum Infectious Diseases, v. 2, issue 4, art. ofv178
Scholar Commons Citation
Carris, Nicholas W.; Pardo, Joe; Montero, Jose; and Shaeer, Kristy M., "Minocycline as A Substitute for Doxycycline in Targeted Scenarios: A Systematic Review" (2015). Internal Medicine Faculty Publications. 117.
https://digitalcommons.usf.edu/intmed_facpub/117
