Major Neurodegenerative Diseases: A Literary Review of Cellular Immunotherapy in Alzheimer’s, Parkinson’s, and Huntington’s Diseases

Authors

Kimberly Sprenger

First Advisor

Hossam M. Ashour, Ph.D. Associate Professor, College of Arts and Sciences

Second Advisor

Suganthi Sridhar, Ph.D. Associate Professor, College of Arts and Sciences

Publisher

University of South Florida St. Petersburg

ISSN

2572-4339

Document Type

Thesis

Date Available

2019-05-01

Publication Date

2019

Date Issued

2019-05-01

Abstract

This thesis paper will focus on the most prominent applications in recent research of immunotherapy in neurodegenerative diseases (specifically Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease) with a focus on the cellular level on inflammatory pathways (such as, but not limited to: NFkB, JNK and anti-inflammatory pathways such as NRf2) present in the human body.

The literary analysis will begin with a basic overview of some of the major homeostatic pathways present in cellular organelles within the human body (such as the Unfolded Protein Response/UPR, present in the endoplasmic reticulum of eukaryotes) and how they normally act within a healthy human body. The paper will then delve deeper into how these cellular processes are altered, including the root causes of these neurodegenerative diseases commonly researched today, and what mutations in the normal homeostatic processes mean for the phenotypic display of these illnesses (how symptoms appear).

The final parts of this literary analysis thesis paper will delve into current research methodologies being performed in the neurodegenerative disease therapy field and how immunotherapy is quickly becoming a lead topic of interest amongst researchers and universities and the benefits (and negatives, if any discovered yet) of using immunotherapy compared to the alternative (and maybe currently less effective) therapeutic treatments.

Comments

A thesis submitted in partial fulfillment of the requirements of the University Honors Program University of South Florida, St. Petersburg April23rd, 2018

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Recommended Citation

Sprenger, Kimberly, "Major Neurodegenerative Diseases: A Literary Review of Cellular Immunotherapy in Alzheimer’s, Parkinson’s, and Huntington’s Diseases" (2019). USF St. Petersburg campus Honors Program Theses (Undergraduate).
https://digitalcommons.usf.edu/honorstheses/245