Graduation Year


Document Type




Degree Name

Doctor of Philosophy (Ph.D.)

Degree Granting Department


Major Professor

Edward Turos, Ph.D.

Committee Member

Dominic P. D'Agostino, Ph.D.

Committee Member

James W. Leahy, Ph.D.

Committee Member

David J. Merkler, Ph.D.


ketogenic diet, ketosis, keto, exogenous ketone supplements, acetoacetate, b-hydroxybutyrate


The ketogenic diet has grown in popularity in the last decade as a weight loss tool. Research into the diet’s effects on the body have revealed a variety of other health benefits. The use of exogenous ketone supplements to confer the benefits of the diet without strict adherence to it represents an exciting new area of focus. Synthetic ketogenic compounds are of particular interest that has received very little emphasis and is an untapped area of focus for chemical synthesis.

The first chapter of this manuscript provides an overview of the history of the ketogenic diet along with a summary of the benefits and limitations of the diet, and the biochemistry behind it. It provides a summary of the current research surrounding synthetic ketogenic compounds and justifies the synthesis of novel synthetic ketogenic compounds.

The second chapter discusses the synthesis of a series of compounds designed with the goal of generating an increase to ketone body levels in the body. The third and fourth chapter discuss in vivo and in vitro testing done on these compounds to justify their use as novel synthetic ketogenic compounds and to justify further research into the field.

Included in

Chemistry Commons