Graduation Year
2021
Document Type
Dissertation
Degree
Ph.D.
Degree Name
Doctor of Philosophy (Ph.D.)
Degree Granting Department
Chemistry
Major Professor
Edward Turos, Ph.D.
Committee Member
Dominic P. D'Agostino, Ph.D.
Committee Member
James W. Leahy, Ph.D.
Committee Member
David J. Merkler, Ph.D.
Keywords
ketogenic diet, ketosis, keto, exogenous ketone supplements, acetoacetate, b-hydroxybutyrate
Abstract
The ketogenic diet has grown in popularity in the last decade as a weight loss tool. Research into the diet’s effects on the body have revealed a variety of other health benefits. The use of exogenous ketone supplements to confer the benefits of the diet without strict adherence to it represents an exciting new area of focus. Synthetic ketogenic compounds are of particular interest that has received very little emphasis and is an untapped area of focus for chemical synthesis.
The first chapter of this manuscript provides an overview of the history of the ketogenic diet along with a summary of the benefits and limitations of the diet, and the biochemistry behind it. It provides a summary of the current research surrounding synthetic ketogenic compounds and justifies the synthesis of novel synthetic ketogenic compounds.
The second chapter discusses the synthesis of a series of compounds designed with the goal of generating an increase to ketone body levels in the body. The third and fourth chapter discuss in vivo and in vitro testing done on these compounds to justify their use as novel synthetic ketogenic compounds and to justify further research into the field.
Scholar Commons Citation
Williams, Michael Scott, "Novel Synthetic Ketogenic Compounds" (2021). USF Tampa Graduate Theses and Dissertations.
https://digitalcommons.usf.edu/etd/9261
