Graduation Year
2019
Document Type
Thesis
Degree
M.S.
Degree Granting Department
College of Pharmacy
Major Professor
Siva Kumar Panguluri, Ph.D.
Committee Member
Manas Biswal, Ph.D.
Committee Member
Jennifer Rodgers, Ph.D.
Keywords
Hospital mortality, Kv channels, Cardiotoxicity, Ventricular remodeling
Abstract
Administration of Hyperoxia (>90 % oxygen) is a pervasive intervention to supplement respiratory needs in patients admitted in ICU/critical care units. Current literature suggests that prolonged use of Hyperoxia therapy is directly associated with in-hospital mortality. The exact reason for this high mortality under Hyperoxia is unknown. Recent explorations in Dr. Panguluri lab identified that dysregulation of Kv channels plays a vital role in the pathophysiology of Hyperoxia-induced pulmonary and cardiac complications using animal models. The proposed research will focus on the part of Hyperoxia in generating cardiotoxicity and ventricular remodeling in the type-1 diabetes patients using the Akita, mouse model.
Scholar Commons Citation
Bolleddu, Samuel Ignatious, "Effect of Hyperoxia on Type-1 Diabetic Mouse Model" (2019). USF Tampa Graduate Theses and Dissertations.
https://digitalcommons.usf.edu/etd/8702
