Graduation Year
2019
Document Type
Dissertation
Degree
Ph.D.
Degree Name
Doctor of Philosophy (Ph.D.)
Degree Granting Department
Chemistry
Major Professor
Jianfeng Cai, Ph.D.
Committee Member
Julie Harmon, Ph.D.
Committee Member
James Leahy, Ph.D.
Committee Member
Xingmin Sun, Ph.D.
Keywords
Bacterial Resistance, Broad Spectrum Therapeutics, Host Defense Peptides, Peptidomimetics
Abstract
For decades it has been convention to use antibiotics for the treatment of bacterial infections. Due to the overuse and misuse of these drugs, bacteria are becoming resistant to these treatments. This phenomenon has led to the search for alternative antibiotics, and in the study of Host Defense Peptides (HDPs). HDPs are the body’s innate immune response to infection. They are known to modulate immune system response and kills bacterial using various methods causing them to be less susceptible to bacterial resistance. The method by which we can mimic these biological peptides is called peptidomimetics. Various research shows the use of peptidomimetics that are active against bacteria by way of β-peptides, peptoids, and AA-peptides. For the following chapters focus will be on the α-AApeptides which were designed and developed within our lab. The stability and flexibility provided by this class of peptides has led to the study of, lipidated α/α-AA heterogeneous peptides as antimicrobial agent, lipidated α/sulfono-α-AA heterogeneous peptides as antimicrobial agents for Gram-positive bacteria, lipidated hydantoin α/α-AA heterogeneous peptides as antimicrobial agents, and the self-assembly of Lipidated α-AA peptides into nanostructures.
Scholar Commons Citation
Singh, Sylvia E., "Development of α-AA peptides as Peptidomimetics for Antimicrobial Therapeutics and The Discovery of Nanostructures" (2019). USF Tampa Graduate Theses and Dissertations.
https://digitalcommons.usf.edu/etd/8686
