Graduation Year


Document Type




Degree Name

Doctor of Philosophy (Ph.D.)

Degree Granting Department


Major Professor

Mildred Acevedo-Duncan, Ph.D.

Committee Member

Wayne C. Guida, Ph.D.

Committee Member

Jainfeng Cai, Ph.D.

Committee Member

Meera Nanjundan, Ph.D.

Committee Member

Marie Bourgeois, Ph.D.


cell viability, apoptosis, ubiquitination, invasion


Lung cancer is the second most common cancer, and it is the leading cause of cancer death in both men and women. Elevated levels of PKC-ι and FAK are implicated in the progression of lung cancer and involved in cell proliferation, apoptosis, cell survival, and cell migration processes. Lung cancer diagnosis typically occurs in the late stages, which limits the treatment options. Hence, there is a dire need to develop drugs that are effective and safe to treat lung cancers. We used a novel aPKC inhibitor named DNDA (3,4-amino-2,7 napthalene disulfonic acid) to study the role of atypical PKCs (aPKCs) in cell proliferation and migration in lung cancer cell lines. Our study demonstrates that DNDA reduced the cell viability, induced apoptosis and inhibited the migration of A549 lung cancer cells by PKC-ι/FAK ubiquitination via Cbl-b pathway. Hence, DNDA is an excellent candidate to treat lung cancers.

Included in

Chemistry Commons