Graduation Year
2019
Document Type
Dissertation
Degree
Ph.D.
Degree Name
Doctor of Philosophy (Ph.D.)
Degree Granting Department
Physics
Major Professor
Sagar A. Pandit, Ph.D.
Committee Member
Ghanim Ullah, Ph.D.
Committee Member
Robert S. Hoy, Ph.D.
Committee Member
Jianjun Pan, Ph.D.
Committee Member
Yicheng Tu, Ph.D.
Keywords
Ether Lipids, Ionic Solvents, Lipid Bilayer, Molecular Simulations
Abstract
Lipid bilayers are important biological structures. The changes in bilayer properties are induced by the composition of the bilayer as well as the solvent. In this work, we study the effects of different molecular makeups of lipids and ionic solvents with molecular dynamics simulations to determine their effect on the bilayer interface. In particular, we look at how different carbon chain bindings affect water viscosity at the interface and allow for a less permeable bilayer. Additionally, we examine the changes to the bilayer due to the presence of the most biologically relevant salt ions. Lastly, we show how the pharmacological ion lithium may replace magnesium due to overlapping solvation shells.
Scholar Commons Citation
Kruczek, James M., "Water and Salt at the Lipid-Solvent Interface" (2019). USF Tampa Graduate Theses and Dissertations.
https://digitalcommons.usf.edu/etd/8380
