Graduation Year

2019

Document Type

Thesis

Degree

M.S.

Degree Name

Master of Science (M.S.)

Degree Granting Department

Biomedical Engineering

Major Professor

William E. Lee III, Ph.D.

Co-Major Professor

Peter Simon, Ph.D.

Committee Member

Robert Frisina, Ph.D.

Committee Member

Sergio Gutierrez, Ph.D.

Keywords

Bone Density, Bone Geometry, Computerized Tomography Scan Study, Sexual Dimorphism

Abstract

The fifth metacarpal bone fracture is a common type of fracture among the young male population. With the increasing demand for early recovery from such fractures with surgical reduction, the medical manufacturers and clinicians are interested in designing a better intramedullary device for fixation. This study is an attempt to investigate the dimensional parameters of the fifth metacarpal bone and its intramedullary canal, using 3D CT scan images of cadaveric hands. The algorithm used for measurement applies principal component analysis on the subject bone, to control the information loss and normalize the spatial position of the subject. This analysis provides a range of measurements for bone-length, the diameter of scribed circles for both the whole bone model and intramedullary canal, as well as the density distribution of the cortical bone. The results indicated that there is a statistically significant relationship between the height of specimen donors with respect to the length of bone, and the diameter of the scribed circles for their intramedullary canal (p < 0.1). As well as, there is a statistically significant correlation between the average density of the cortical bone with respect to the weight and BMI of the donor specimen (p ≤ 0.05). However, the correlation was less evident in the female population than compared to that of the male population. These measurements evidence enough variability within the demography, suggesting a requirement for a wider range of devices to cater to a diverse patient population.

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