Graduation Year
2017
Document Type
Dissertation
Degree
Ph.D.
Degree Name
Doctor of Philosophy (Ph.D.)
Degree Granting Department
Chemistry
Major Professor
Bill J. Baker, Ph.D.
Committee Member
Lindsey N. Shaw, Ph.D.
Committee Member
James W. Leahy, Ph.D.
Committee Member
Edward Turos, Ph.D.
Keywords
screening, epigenetic modification, Phomopsis, Penicillium, ESKAPE, Leishmaniasis
Abstract
Natural products have, historically, played an important role in drug discovery. Nevertheless, drug resistance, pathogen evolution, and global climate change threaten human health and nearly all current anti-infective treatments on the market today. It is undeniable that new drug discovery efforts are needed with increasing urgency.
Bolstered by a rich history of discovering treatments in the world around us, natural products chemists continue to look to the environment with increasing understanding and emerging technologies that allow efficient, effective isolation of new chemical entities. This thesis will describe one such endeavor.
Focusing on fungal natural products, herein is described the isolation and structure elucidation of new, bio-active natural products. Further, the development and implementation of a large fungal screening program will be discussed, the results of which stand to advance microbial drug discovery in the Baker lab for years to come.
Scholar Commons Citation
Demers, Danielle H., "Chemical Investigations of Fungal Natural Products for Drug Discovery" (2017). USF Tampa Graduate Theses and Dissertations.
https://digitalcommons.usf.edu/etd/6825
