Jazmine Aira

Graduation Year

2016

Document Type

Thesis

Degree

M.S.B.E.

Degree Name

MS in Biomedical Engineering (M.S.B.E.)

Degree Granting Department

Chemical Engineering

Major Professor

William E. Lee III, Ph.D.

Co-Major Professor

Peter Simon, Ph.D.

Committee Member

Stephanie Carey, Ph.D.

Keywords

Bone Geometry, Computerized Tomography (CT) Scan Study, Sexual Dimorphism, Laterality, Endomedullary Devices

Abstract

Midshaft clavicle fractures are very common. Current treatment of choice involves internal fixation with superior or anterior clavicle plating, however their clinical success and patient satisfaction are slowly decreasing. The design of intramedullary (IM) devices is on the rise, but data describing the IM canal parameters is lacking. The aim of this study is to quantify morphometry of the clavicle and its IM canal, and to evaluate the effect of gender and anatomical side. This study used 3-dimensional (3D) image-based models with novel and automated methods of standardization, normalization and bone cross-section evaluation. The data obtained in this thesis presents IM canal and clavicle radius and center deviation parameterized as a function of clavicle length, in addition, its radius of curvature and true length. Results showed that right-sided clavicles tended to be shorter and thicker than left-sided, but only males showed a statistically significant difference in size compared to females (p<.0001). The smallest IM canal and clavicle radii were seen at different clavicle lengths (54% and 49%), suggesting that the narrowest region of IM canal cannot be appreciated based on external visualization of the clavicle alone. The narrowing of the IM canal is of special interest because this a potential limiting region for IM device design. Furthermore, the location and value of maximum lateral curvature displacement is different in the IM canal, implying there exists an eccentricity of the IM canal center with respect to the clavicle center.

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