Graduation Year
2025
Document Type
Dissertation
Degree
Ph.D.
Degree Name
Doctor of Philosophy (Ph.D.)
Degree Granting Department
Chemistry
Major Professor
James W. Leahy, Ph.D.
Committee Member
David Merkler, Ph.D.
Committee Member
Edward Turos, Ph.D.
Committee Member
Lawrence Stern, Ph.D.
Keywords
activity-based proteomic profiling probe, drug development, medicinal chemistry, Photo-affinity probe
Abstract
Fatty acid amides are a large family of endogenous metabolites with significant biological activity, including that of the endocannabinoid system. Currently little is known about how this system of tightly regulated compounds works within humans. This work lays the foundation to explore the structure-activity relationship driving the selectivity of ligand-protein interactions involved with fatty acid amides. A library of activity-based proteomic profiling probes for fatty acid amides has been synthesized to this end. Additionally, progress towards phytocannabinoid probes has been made as well.
Scholar Commons Citation
Feeney, Robert E. III, "The Synthesis of a Photo-Affinity Probe Library for the Fatty Acid Amide Proteome and the Endocannabinoid System Within" (2025). USF Tampa Graduate Theses and Dissertations.
https://digitalcommons.usf.edu/etd/10860
