Graduation Year
2024
Document Type
Dissertation
Degree
Ph.D.
Degree Name
Doctor of Philosophy (Ph.D.)
Degree Granting Department
Chemistry
Major Professor
James W. Leahy, Ph.D.
Committee Member
Bill Baker, Ph.D.
Committee Member
Kirpal Bisht, Ph.D.
Committee Member
Danielle Gulick, Ph.D.
Abstract
Total synthesis is a discipline within organic chemistry that is a constant force that propels the field forward. In our lab, we have immersed ourselves within the field of total synthesis to gain access to complex natural products, perform SAR studies, as well as highlight interesting methodology. Within these endeavors, we have completed the first asymmetric synthesis of membranolide. This has allowed us to explore potential biofilm eradication in our efforts to develop novel therapeutics to combat the ESKAPE pathogens and multi-drug resistance. We have also begun to pursue the first asymmetric total synthesis of the oxeatamides. By utilizing our previous methods, we plan to evaluate the oxeatamides as potential biofilm eradication agents, as well as confirm their structural assignments.
Scholar Commons Citation
Bradley, Sean, "The Asymmetric Total Synthesis of Membranolide and Efforts Towards the Oxeatamides" (2024). USF Tampa Graduate Theses and Dissertations.
https://digitalcommons.usf.edu/etd/10476
