Graduation Year
2023
Document Type
Dissertation
Degree
Ph.D.
Degree Name
Doctor of Philosophy (Ph.D.)
Degree Granting Department
Chemistry
Major Professor
Edward Turos, Ph.D.
Committee Member
Kirpal Bisht, Ph.D.
Committee Member
Jianfeng Cai, Ph.D.
Committee Member
Dominic D’Agostino, Ph.D.
Keywords
Ketogenic, ketone bodies, ketosis, ester, polyol, acetoacetate, medium chain, enzyme, O-acylated, hydrolysis
Abstract
The ketogenic diet has gained popularity in the past few decades among people and physicians due to its various health benefits. A significant amount of research has been done for the modification of the original ketogenic diet and investigation of its potential health benefits. However, synthesis of novel ketogenic compounds as a dietary supplement has not received the same level of attention. That is the primary objective of this research project. The first chapter of this manuscript describes the synthesis of various short and medium chain esters of different polyols that have been done so far, and areas of their uses considering these molecules are the most significant candidates for identifying novel ketogenic compounds. The second chapter discusses biochemistry of the ketogenic diet, synthesis and characterization of a series of molecules with an aim for their potential use as a ketogenic supplement. The third chapter discusses the synthesized compounds’ stability in different chemical environments, their enzymatic hydrolysis activity which mimics that likely to occur in the human body and finally testing of these compounds in animal models to examine their potential ketogenicity.
Scholar Commons Citation
Sakib, Mohammad Nazmus, "Synthetic Studies of Potential New Ketogenic Molecules" (2023). USF Tampa Graduate Theses and Dissertations.
https://digitalcommons.usf.edu/etd/10086
