Document Type
Article
Publication Date
7-2018
Digital Object Identifier (DOI)
https://doi.org/10.1371/journal.pone.0199745
Abstract
Objective: To evaluate improvement in survival of lymphoma patients from 1990 to 2014, stratified by age, sex and race using Surveillance Epidemiology and End-Result Survey Program (SEER) data.
Study Design and Setting: We identified 113,788 incident lymphoma cases from nine SEER cancer registries were followed up for cause-specific mortality from lymphoma. Cox proportional hazard regression was used to estimate hazard ratios (HRs) and their respective 95% confidence interval (CIs) for various time periods within groups stratified by race, age and sex.
Results: Five-year survival for Hodgkin’s lymphoma (HL) was 89% for patients 20–49 years of age. For this age group, compared to 1990–1994, survival significantly improved in 2000–2004 (HR = 0.65; 95% CI: 0.54–0.78), 2005–2009 (HR = 0.46, 95% CI: 0.38–0.57) and 2010–2014 (HR = 0.29, 95% CI: 0.20–0.41). Hodgkin’s lymphoma patients aged 75–85 years had 5-year survival of 37% and in these patients, compared to 1990-1994, survival only improved from 2005 onward (HR = 0.67, 95% CI: 0.50–0.90). In patients with non-Hodgkin’s Lymphoma (NHL), all age groups showed survival improvements between 1990–1994 period and 2010–2014 period. Improvements in HL and NHL survival were seen for all race categories and both genders.
Conclusion: Survival among US lymphoma patients has improved substantially between 1990–1994 period and 2010–2014 period, though disease-specific mortality was still higher in older age groups.
Rights Information
This work is licensed under a Creative Commons Attribution 4.0 License.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
PLoS ONE, v. 13, issue 7, art. e0199745
Scholar Commons Citation
Mukhtar, Fahad; Boffetta, Paolo; Dabo, Bashir; Park, Jong Y.; Tran, Chi T. D.; Tran, Thuan V.; Thi-Thanh Tran, Hong; Whitney, Madison; Risch, Harvey A.; Le, Linh C.; Zheng, Wei; Shu, Xiao-Ou; and Luu, Hung N., "Disparities by Race, Age, and Sex in the Improvement of Survival for Lymphoma: Findings from a Population-based Study" (2018). Epidemiology and Biostatistics Faculty Publications. 6.
https://digitalcommons.usf.edu/epb_facpub/6
