Effects of Apolipoprotein E-ε4 and -ε2 in Amnestic Mild Cognitive Impairment and Dementia in Shanghai: SCOBHI-P
Document Type
Article
Publication Date
2010
Keywords
apolipoprotein E, dementia, mild cognitive impairment, China
Digital Object Identifier (DOI)
https://doi.org/10.1177/1533317509357736
Abstract
Objective: To determine apolipoprotein E (APOE)-ε4 and -ε2 frequencies and risk of mild cognitive impairment (MCI) and dementia in Shanghai, China. Methods: A total of 34 MCI and 34 dementia cases were recruited from an urban Memory Disorders Clinic and 32 controls were recruited from a residential community served by the clinic. Apolipoprotein E was genotyped using standard methods. Results: Among controls, frequencies were ε2, 0.11; ε3, 0.84; and ε4, 0.05; among MCI, 0.05, 0.77, and 0.18; and for dementia, 0.02, 0.84, and 0.15, respectively. In education-adjusted models, the odds ratio (OR) = 5.6 for dementia (95% CI = 1.09-29.3) and 4.7 for MCI (95% CI = 0.90-25.2) associated with any ε4 allele. The ε2 allele was inversely associated with dementia (OR = 0.12, 95% CI = 0.013-0.997) and MCI (OR = 0.38, 95% CI = 0.08-1.61). Conclusions: APOE-ε4 increases and -ε2 decreases the risk of dementia vs normal cognition. Similar trends were observed for amnestic mild cognitive impairment (aMCI).
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
American Journal of Alzheimer's Disease & Other Dementias®, v. 25, issue 3, p. 233-238
Scholar Commons Citation
Borenstein, Amy R.; Mortimer, James A.; Ding, Ding; Schellenberg, Gerard D.; DeCarli, Charles; Zhao, Qianhua; Copenhaver, Cathleen; Guo, Qihao; Chu, Shugang; Galasko, Douglas; Salmon, David P.; Dai, Qi; Wu, Yougui; Petersen, Ronald; and Hong, Zhen, "Effects of Apolipoprotein E-ε4 and -ε2 in Amnestic Mild Cognitive Impairment and Dementia in Shanghai: SCOBHI-P" (2010). Epidemiology and Biostatistics Faculty Publications. 28.
https://digitalcommons.usf.edu/epb_facpub/28
