Digital Object Identifier (DOI)
Gold‐catalyzed alkyne hydration was studied by using in situ reacting mass spectrometry (MS) technology. By monitoring the reaction process in solution under different conditions (regular and very diluted catalyst concentrations, different pH values) and examining the reaction occurrence in the early reaction stage (1–2 ms after mixing) with MS, we collected a series of experimental evidence to support that the bis‐gold complex is a potential key reaction intermediate. Furthermore, both experimental and computational studies confirmed that the σ,π‐bis‐gold complexes are not active intermediates toward nucleophilic addition. Instead, formation of geminally diaurated complex C is crucial for this catalytic process.
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Citation / Publisher Attribution
Chemistry – A European Journal, v. 24, issue 9, p. 2144-2150
This is the peer reviewed version of the following article: M. Lu, Y. Su, P. Zhao, X. Ye, Y. Cai, X. Shi, E. Masson, F. Li, J. L. Campbell, H. Chen, Chem. Eur. J. 2018, 24, 2144., which has been published in final form at 10.1002/chem.201703666. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Scholar Commons Citation
Lu, Mei; Su, Yijin; Zhao, Pengyi; Ye, Xiaohan; Cai, Yi; Shi, Xiaodong; Masson, Eric; Li, Fengyao; Campbell, J. L.; and Chen, Hao, "Direct Evidence for the Origin of Bis‐Gold Intermediates: Probing Gold Catalysis with Mass Spectrometry" (2018). Chemistry Faculty Publications. 96.