Synthesis and Application of a Novel Bis-1,2,3-Triazole Ligand containing a 2,2’-Bipyrrolidine Core
1, 2, 3-Triazole, gold catalysis, alkyne hydration
Digital Object Identifier (DOI)
Herein, we describe the synthesis of a novel bis-1,2,3-triazole ligand which contains an internal N-alkylated 2,2’-bipyrrolidine linker. By using simple starting materials, the ligand could be generated in good yield through several synthetic steps. To investigate the potential for the application of this ligand in transition metal catalysis, we generated a bis-Au(I) complex in nearly quantitative yield and examined its reactivity in the context of alkyne hydration. Both alkyl and aryl terminal alkynes could be efficiently converted to their corresponding ketones in nearly quantitative yields with only 1% catalyst loading under mild conditions.
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Citation / Publisher Attribution
Arkivoc, v. 2018, issue 2, p. 280-287
Scholar Commons Citation
Motika, Stephen and Shi, Xiaodong, "Synthesis and Application of a Novel Bis-1,2,3-Triazole Ligand containing a 2,2’-Bipyrrolidine Core" (2018). Chemistry Faculty Publications. 55.