Document Type


Publication Date



Cancer therapy, Nanoparticles

Digital Object Identifier (DOI)


The most common cancer treatments currently available are radio- and chemo-therapy. These therapies have, however, drawbacks, such as, the reduction in quality of life and the low efficiency of radiotherapy in cases of multiple metastases. To lessen these effects, we have encapsulated an anti-cancer drug into a biocompatible matrix. In-vitro assays indicate that this bio-nanocomposite is able to interact and cause morphological changes in cancer cells. Meanwhile, no alterations were observed in monocytes and fibroblasts, indicating that this system might carry the drug in living organisms with reduced clearance rate and toxicity. X-rays and neutrons were used to investigate the carrier structure, as well as to assess the drug mobility within the bio-nanocomposite. From these unique data we show that partial mobility restriction of active groups of the drug molecule suggests why this carrier design is potentially safer to healthy cells.

Rights Information

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

Was this content written or created while at USF?


Citation / Publisher Attribution

Scientific Reports, v. 6, art. 22478

Supplementary information.pdf (1968 kB)
Supplementary information

Supplementary Movie (1018 kB)
Movie S1

Supplementary Movie (864 kB)
Movie S2

Supplementary Movie (1056 kB)
Movie S3

Supplementary Movie (895 kB)
Movie S4

Supplementary Movie (688 kB)
Movie S5

Supplementary Movie (692 kB)
Movie S6

Supplementary Movie (888 kB)
Movie S7

Supplementary Movie (544 kB)
Movie S8

Supplementary Movie (567 kB)
Movie S9

Included in

Chemistry Commons