Restricted Mobility of Specific Functional Groups Reduces Anti-cancer Drug Activity in Healthy Cells

Authors

Murillo L. Martins, University of Copenhagen
Rosanna Ignazzi, University of Copenhagen
Juergen Eckert, University of South FloridaFollow
Benjamin Watts, Paul Scherrer Institute
Ramon Kaneno, Universidade Estadual Paulista
Willian F Zambuzzi, Universidade Estadual Paulista
Luke Daemen, Los Alamos National Laboratory
Margarida J Saeki, Universidade Estadual Paulista
Heloisa N Bordallo, University of Copenhagen

Document Type

Article

Publication Date

3-2-2016

Keywords

Cancer therapy, Nanoparticles

Digital Object Identifier (DOI)

https://doi.org/10.1038/srep22478

Abstract

The most common cancer treatments currently available are radio- and chemo-therapy. These therapies have, however, drawbacks, such as, the reduction in quality of life and the low efficiency of radiotherapy in cases of multiple metastases. To lessen these effects, we have encapsulated an anti-cancer drug into a biocompatible matrix. In-vitro assays indicate that this bio-nanocomposite is able to interact and cause morphological changes in cancer cells. Meanwhile, no alterations were observed in monocytes and fibroblasts, indicating that this system might carry the drug in living organisms with reduced clearance rate and toxicity. X-rays and neutrons were used to investigate the carrier structure, as well as to assess the drug mobility within the bio-nanocomposite. From these unique data we show that partial mobility restriction of active groups of the drug molecule suggests why this carrier design is potentially safer to healthy cells.

Rights Information

This work is licensed under a Creative Commons Attribution 4.0 License.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Scientific Reports, v. 6, art. 22478

Scholar Commons Citation

Martins, Murillo L.; Ignazzi, Rosanna; Eckert, Juergen; Watts, Benjamin; Kaneno, Ramon; Zambuzzi, Willian F; Daemen, Luke; Saeki, Margarida J; and Bordallo, Heloisa N, "Restricted Mobility of Specific Functional Groups Reduces Anti-cancer Drug Activity in Healthy Cells" (2016). Chemistry Faculty Publications. 26.
https://digitalcommons.usf.edu/chm_facpub/26