Synthesis and Activity of a New Series of Antileishmanial Agents
Digital Object Identifier (DOI)
We have determined that tetrahydroindazoles such as 1 show potent activity against Leishmania donovani, the causative agent of leishmaniasis. While the Hsp90 activity and anticancer properties of 1 have previously been explored, we present here our efforts to optimize their activity against L. donovani via the synthesis of novel analogues designed to probe the hydrophobic pocket of the protozoan Hsp90 orthologue, specifically through the auspices of functionalization of an amine embedded into the scaffold.
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Citation / Publisher Attribution
ACS Medicinal Chemistry Letters, v. 8, issue 8, p. 797-801
Scholar Commons Citation
Kanwar, Ankush; Eduful, Benjamin J.; Barbeto, Linda; Bonomo, Piero Carletti; Lemus, Andrea; Vesely, Brian A.; Mutka, Tina S.; Azhari, Ala; Kyle, Dennis E.; and Leahy, James W., "Synthesis and Activity of a New Series of Antileishmanial Agents" (2017). Chemistry Faculty Publications. 183.